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  • Title: A convergent ring-closing metathesis approach to carbohydrate-based macrolides with potential antibiotic activity.
    Author: Blom P, Ruttens B, Van Hoof S, Hubrecht I, Van der Eycken J, Sas B, Van hemel J, Vandenkerckhove J.
    Journal: J Org Chem; 2005 Nov 25; 70(24):10109-12. PubMed ID: 16292849.
    Abstract:
    [reaction: see text] An efficient convergent approach has been developed for the construction of novel, non-natural, carbohydrate-based macrolides. The key step in the synthesis is the formation of the macrocyclic ring via a ring-closing metathesis reaction. The obtained macrolide analogues have been screened for biological activity against gram-positive and gram-negative bacteria, including resistant strains, yeasts, and molds.
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