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  • Title: Ganciclovir implant in the treatment of cytomegalovirus retinitis.
    Author: Chang M, Dunn JP.
    Journal: Expert Rev Med Devices; 2005 Jul; 2(4):421-7. PubMed ID: 16293081.
    Abstract:
    The ganciclovir implant is a sustained-release intraocular drug delivery system used to treat cytomegalovirus retinitis that provides a high and steady-state concentration of the drug in the vitreous cavity over a period of 7-8 months. Randomized, controlled clinical trials have demonstrated a superior efficacy of the implant compared with intravenous ganciclovir. Severe adverse events associated with the implant are uncommon, though potentially blinding. In addition, the implant provides no protection against second-eye or visceral cytomegalovirus retinitis infections. This review summarizes the clinical indications for and complications associated with the ganciclovir implant.
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