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  • Title: Gastrointestinal nematode infection is associated with variation in innate immune responsiveness.
    Author: Jackson JA, Turner JD, Kamal M, Wright V, Bickle Q, Else KJ, Ramsan M, Bradley JE.
    Journal: Microbes Infect; 2006 Feb; 8(2):487-92. PubMed ID: 16293435.
    Abstract:
    Ex vivo monocyte cytokine responses (IL-1beta, TNF-alpha, IL-12p70, IL-10, TGF-beta) to bacterial TLR2 and TLR4 ligands were quantified in 47 gastrointestinal (GI) nematode-exposed children in Pemba Island, Tanzania. Worminess (estimated by faecal egg counts (FEC)) had a positive relationship with pro-inflammatory TNF-alpha and IL-1beta responsiveness to the TLR ligands. In particular, there was a strong significant relationship with TNF-alpha response to TLR4 ligand (LPS). There were no significant associations between regulatory responses (IL-10, TGF-beta) and worminess. These results are consistent with the possibility that GI nematodes modulate innate responses and may indicate a potential mechanism for interactions between GI nematodiasis and important bystander pathogens.
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