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  • Title: Biological, physical factors in clinical assessment of outcome of cancer therapy.
    Author: Perez CA.
    Journal: Rays; 2005; 30(2):85-98. PubMed ID: 16294900.
    Abstract:
    Complex molecular and cellular biological phenomena influence the response of tumor and normal cell to cytotoxic agents, including irradiation. Innovative 3-D treatment planning and IGRT techniques allow more quantitative optmization of irradiation dose distribution in target volumes and OAR. More detailed reporting on radiation doses is required with incorporation of biological parameters in treatment planning and dose specification. TCP and NTCP models should be validate with actual clinical data. Quality assurance in radiation oncology is mandatory. Because of increasing concerns with health care costs, technology assessment and cost benefit studies should be an integral component of clinical outcome reporting.
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