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  • Title: Antiphospholipid antibodies--our experience.
    Author: Srikrishna A, Sitalakshmi S, Devi S, Damodar P, Varghese J, Suresh J, Mathew T.
    Journal: Indian J Pathol Microbiol; 2004 Apr; 47(2):174-7. PubMed ID: 16295461.
    Abstract:
    Antiphospholipid antibodies (APA) have aroused multispeciality interests. In our study of 200 cases worked up for APA, we have used a few simple coagulation tests to detect lupus anticoagulant (LA) and ELISA to detect anticardiolipin antibodies. The positivity rate for LA among cases with recurrent pregnancy loss was 4.16% and for aCL 20.8%. The positivity rate for LA in patients with venous thrombosis was 6.2%, in arterial thrombosis was 7.14% and in SLE patients was 58.3%. In conclusion APAs are to be looked for in cases of recurrent pregnancy loss, thrombosis in people < 45 years of age without risk factors and SLE patients to assess the thrombotic risk and to decide on anti coagulant therapy for further management.
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