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Title: Enhancement of endogenous release of glutamate and gamma-aminobutyric acid from hippocampus CA1 slices after in vivo long-term potentiation. Author: Ghijsen WE, Besselsen E, Geukers V, Kamphuis W, Lopes da Silva FH. Journal: J Neurochem; 1992 Aug; 59(2):482-6. PubMed ID: 1629721. Abstract: The effect of long-term potentiation (LTP) on endogenous amino acid release from rat hippocampus slices was studied. LTP was induced in vivo by application of a tetanus (200 Hz, 200 ms) to the Schaffer collateral fibers in unanesthetized rats. Endogenous release of glutamate and gamma-aminobutyric acid (GABA) was investigated 60 min after tetanization in CA1 subslices of potentiated and control rats. No significant effects of LTP were observed in basal and K(+)-induced Ca(2+)-independent release components of these amino acids. In contrast, K(+)-induced Ca(2+)-dependent release of both glutamate and GABA increased approximately 100% in slices from potentiated rats. No differences were observed in total content of glutamate and GABA between the subslices from control and LTP animals. These results suggest a persistent increase in the recruitment of the presynaptic vesicular pool of glutamate and GABA during LTP.[Abstract] [Full Text] [Related] [New Search]