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  • Title: Experience of Mars therapy with and without transplantation in 101 patients with liver insufficiency.
    Author: Koivusalo AM, Vakkuri A, Höckerstedt K, Isoniemi H.
    Journal: Transplant Proc; 2005 Oct; 37(8):3315-7. PubMed ID: 16298584.
    Abstract:
    Liver support devices are used to treat life-threatening organ dysfunction until a hepatic graft is available or recovery of the native liver. We used a blood purification system--molecular adsorbent recycling system (MARS)--that is based on removal of both protein-bound and water-soluble substances and toxins. Within 2.5 years we treated 101 patients, who were stratified to three subgroups: acute liver failure (ALF; n = 56), acute decompensation in chronic liver failure (AcOCh; n = 35) and liver graft failure (n = 10). MARS seems to be a promising therapy for ALF, allowing the patient's own liver to recover or to gain enough time to find a liver graft. The most promising results, namely the highest number of livers to recovery were observed among acute patients with liver failure due to a toxic etiology. However, we did not discover much benefit of MARS for patients with AcOCh without liver transplantation.
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