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  • Title: Therapeutical effects of PPAR agonists assessed by biomarker modulation.
    Author: Chinetti-Gbaguidi G, Fruchart JC, Staels B.
    Journal: Biomarkers; 2005 Nov; 10 Suppl 1():S30-6. PubMed ID: 16298909.
    Abstract:
    The metabolic syndrome is defined as the clustering of cardiovascular risk factors, such as glucose intolerance, hyperinsulinemia, dyslipidemia, coagulation disturbances and hypertension. Activators of the nuclear receptors peroxisome proliferator-activated receptors (PPARs) modulate several of the metabolic risk factors pre-disposing to atherosclerosis. Fibrates are hypolipidemic drugs operating through activation of PPARalpha, whereas glitazones are insulin sensitizers activating PPARgamma. In addition, these drugs exert pleiotropic and anti-inflammatory actions. This review will focus on the different effects of fibrates and glitazones, as measured by biomarker modulation, on the development of atherosclerosis and cardiovascular disease.
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