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  • Title: TIRs of joy: new receptors for auxin.
    Author: Napier RM.
    Journal: Bioessays; 2005 Dec; 27(12):1213-7. PubMed ID: 16299761.
    Abstract:
    Back-to-back papers have described the identification of a family of receptors for the plant hormone auxin. Most developmental processes in plants are dependent on auxin signalling making this discovery a landmark in the search for the mechanism of auxin action. The TIR1 gene translates into a protein with recognised motifs including an F-box domain and TIR1 forms part of an important ubiquitination complex that tags other proteins for degradation. Specific amongst the targets of TIR1 are a set of auxin-regulated transcription factors. The latest work has shown that TIR1 itself is also the binding site for auxin making it an auxin receptor with no requirement for a biochemical signalling cascade.
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