These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Design and total synthesis of a fluorescent phorboxazole A analog for cellular studies.
    Author: Chen J, Ying L, Hansen TM, Engler MM, Lee CS, La Clair JJ, Forsyth CJ.
    Journal: Bioorg Med Chem Lett; 2006 Feb 15; 16(4):901-4. PubMed ID: 16300946.
    Abstract:
    To enable studies to elucidate the intracellular processing and targeting of the potent cytostatic/apoptotic anticancer natural products phorboxazoles A and B, a fluorescent derivative has been developed. This involved the total syntheses of the terminal alkyne 33-O-Me-45,46-dehydrobromophorboxazole A (MDHBPA) and a terminal vinyl iodide derivative of the blue fluorescent dye N,N,-dimethyl-7-aminocoumarin (DMC). Sonogashira coupling of these partners provided enyne DMC-MDHBPA in high yield.
    [Abstract] [Full Text] [Related] [New Search]