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  • Title: Autologous transplantation of CD133 selected hematopoietic progenitor cells for treatment of relapsed acute lymphoblastic leukemia.
    Author: Barfield RC, Hale GA, Burnette K, Behm FG, Knapp K, Eldridge P, Handgretinger R.
    Journal: Pediatr Blood Cancer; 2007 Mar; 48(3):349-53. PubMed ID: 16302216.
    Abstract:
    A 21-year-old white male with relapsed acute lymphoblastic leukemia (ALL) developed an invasive Zygomycosis infection 3 weeks after beginning re-induction chemotherapy. Because of the high risk of fatal recurrence of the fungal infection, neither long-term maintenance chemotherapy nor allogeneic hematopoietic stem cell transplant (HSCT) was considered appropriate. Because his ALL blasts expressed CD34 but lacked CD133, he received a CD133 selected autologous graft following high-dose consolidation chemotherapy. The patient survives in remission 19 months after HSCT.
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