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  • Title: Synthesis of 2,5-thiazole butanoic acids as potent and selective alpha(v)beta3 integrin receptor antagonists with improved oral pharmacokinetic properties.
    Author: Wendt JA, Wu H, Stenmark HG, Boys ML, Downs VL, Penning TD, Chen BB, Wang Y, Duffin T, Finn MB, Keene JL, Engleman VW, Freeman SK, Hanneke ML, Shannon KE, Nickols MA, Steininger CN, Westlin M, Klover JA, Westlin W, Nickols GA, Russell MA.
    Journal: Bioorg Med Chem Lett; 2006 Feb 15; 16(4):845-9. PubMed ID: 16303301.
    Abstract:
    We describe a series of 2,5 thiazole containing compounds, which are potent antagonists of the integrin alpha(v)beta3 and show selectivity relative to the other integrins, such as alpha(IIb)beta3 and alpha(v)beta6. These analogs were demonstrated to have high bioavailability relative to other relative heterocyclic analogs.
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