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  • Title: Kinetics of interaction of local anesthetics with human serum albumin.
    Author: Galenko-Yaroshevskii AP, Fistunenko PN, Dukhanin AS.
    Journal: Bull Exp Biol Med; 2005 Sep; 140(3):315-6. PubMed ID: 16307046.
    Abstract:
    We studied kinetic parameters of interaction of local anesthetics (lidocaine, tetracaine, bupivacaine, and two novel agents with proved local anesthetic potency RU-353 and RU-1117) with human serum albumin. Complexation of local anesthetics with human serum albumin is a time-dependent and reversible process; equilibrium was attained within 1.5-4.5 h depending on chemical nature of local anesthetics.
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