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Title: Isolation, synthesis, and anti-tumor activities of a novel class of podocarpic diterpenes. Author: Xiong Y, Wang K, Pan Y, Sun H, Tu J. Journal: Bioorg Med Chem Lett; 2006 Feb 15; 16(4):786-9. PubMed ID: 16309905. Abstract: A novel unusual 17-carbon diterpenoid, named (+)-7-deoxynimbidiol, was isolated from the stalks of Celastrus hypoleucus (Oliv.) Warb. Its racemate and derivatives were synthesized, and the inhibitory activities of these compounds against four cultured human-tumor cell lines were evaluated. The structure-activity relationship was discussed.[Abstract] [Full Text] [Related] [New Search]