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  • Title: Soft x-ray therapy for cutaneous basal cell and squamous cell carcinomas.
    Author: Schulte KW, Lippold A, Auras C, Bramkamp G, Breitkopf C, Elsmann HJ, Habenicht EM, Jasnoch V, Müller-Pannes H, Rupprecht R, Suter L.
    Journal: J Am Acad Dermatol; 2005 Dec; 53(6):993-1001. PubMed ID: 16310060.
    Abstract:
    BACKGROUND: We have used a schedule for soft x-ray therapy of epithelial malignancies that takes into account the clinically diagnosed tumor involution under treatment. OBJECTIVE: We sought to evaluate the effectiveness of this schedule in terms of cure rate and late ulcerations. METHODS: Patients with 1267 consecutively irradiated (1988-1992) basal cell and squamous cell carcinomas were followed up (average 77 months). RESULTS: The recurrence rate (5.1%) was related to tumor size and thickness and to the time-dose-fractionation factor. The frequency of ulcerations (6.3%) depended on field size, hardness of the x-rays, and in smaller fields (diameter up to 4 cm) on total dose, and time-dose-fractionation factor. Of all ulcerations, 82.5 % could be conservatively cured. LIMITATIONS: We have no evidence that our radiation schedule is superior to those published by other authors. CONCLUSION: These results verify the usefulness of soft x-ray therapy for cutaneous epithelial malignancies.
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