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  • Title: New 1,3,4-thiadiazole derivatives endowed with analgesic and anti-inflammatory activities.
    Author: Schenone S, Brullo C, Bruno O, Bondavalli F, Ranise A, Filippelli W, Rinaldi B, Capuano A, Falcone G.
    Journal: Bioorg Med Chem; 2006 Mar 15; 14(6):1698-705. PubMed ID: 16310359.
    Abstract:
    Two series of N-[5-oxo-4-(arylsulfonyl)-4,5-dihydro-1,3,4-thiadiazol-2-yl]-amides were synthesized and tested in vivo for their analgesic and anti-inflammatory activities. All the new compounds possess good antalgic action in the acetic acid writhing test and some terms of the series showed also fair anti-inflammatory activity in the carrageenan rat paw edema test. Ulcerogenic and irritative action on the gastrointestinal mucose, in comparison with indomethacin is low.
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