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  • Title: Low levels of pigment epithelium-derived factor in highly myopic eyes with chorioretinal atrophy.
    Author: Ogata N, Imaizumi M, Miyashiro M, Arichi M, Matsuoka M, Ando A, Matsumura M.
    Journal: Am J Ophthalmol; 2005 Nov; 140(5):937-9. PubMed ID: 16310484.
    Abstract:
    PURPOSE: To determine the concentration of pigment epithelium-derived factor (PEDF) in the aqueous humor of highly myopic eyes. DESIGN: Observational case series. METHODS: The PEDF concentration in the aqueous humor of 23 eyes of 17 patients with high myopia (axial length >26 mm) who underwent cataract surgery was measured by enzyme-linked immunosorbent assay. RESULTS: The mean concentration of PEDF in eyes with high myopia (0.54 +/- 0.12 microg/ml) was significantly lower than that in control eyes (0.86 +/- 0.04 microg/ml, P = .0022). The PEDF level in myopic eyes with chorioretinal atrophy (0.32 +/- 0.05 microg/ml) was lower than that in myopic eyes without chorioretinal atrophy (0.71 +/- 0.12 microg/ml; P = .041) and control eyes (P = .0003). CONCLUSIONS: The significantly lower concentration of PEDF in eyes with chorioretinal atrophy-associated high myopia probably resulted from degeneration of the retinal pigment epithelial cells and/or the retinal ganglion cells that are the main sources of PEDF in the eye.
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