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  • Title: CIITA transformation rescues the apoptotic function of MHC class II in melanoma cells.
    Author: Le E, Zhang H, Blanck G.
    Journal: Anticancer Res; 2005; 25(6B):3889-92. PubMed ID: 16312044.
    Abstract:
    BACKGROUND: Cell-surface major histocompatibility (MHC) class II molecules contribute to a molecular, intercellular complex that stimulates T-cells. MHC class II molecules also activate signaling pathways leading to apoptosis. Lack of CIITA, a co-activator of the MHC class II gene promoter, is responsible for lack of MHC class II on most of the MHC class II-negative melanoma cell lines. MATERIALS AND METHODS: We rescued CIITA and MHC class II expression in melanoma cell lines by stable transformation with a CIITA expression vector and assayed for MHC class II-mediated apoptosis. RESULTS: Reconstitution of CIITA in multiple CIITA-negative melanoma lines restores the apoptotic function of melanoma MHC class II. CONCLUSION: Lack of MHC class II transcription, rather than defects in MHC class II protein function or defects in the other components of the MHC class II-stimulated apoptotic pathway, prevents MHC class II-mediated apoptosis in melanoma cells.
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