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  • Title: Polymer-assisted solution-phase chemical library synthesis.
    Author: Parlow JJ.
    Journal: Curr Opin Drug Discov Devel; 2005 Nov; 8(6):757-75. PubMed ID: 16312151.
    Abstract:
    Polymer-assisted solution-phase (PASP) synthesis has become a prevalent method for the parallel synthesis of chemical libraries. PASP methodology enables the chemist to prepare libraries of compounds more quickly and efficiently than previously. PASP technology encompasses a number of purification techniques for intermediate and final product purification. This methodology continues to progress, providing the practitioner with a broad range of ingenious purification methods, enabling multi-step syntheses of complex compounds. This review covers significant new advances in the use of tagged-reagents/substrates, resin capture-release techniques and PASP multi-step synthesis, some of which incorporate microwave heating and automation.
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