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  • Title: [Effects of glycyrrhizin on TGFbeta1 stimulated hepatic stellate cell signaling transduction].
    Author: Dong L, Sun JY, Fang GT, Jiang LD, Wang JY.
    Journal: Zhonghua Gan Zang Bing Za Zhi; 2005 Nov; 13(11):828-31. PubMed ID: 16313727.
    Abstract:
    OBJECTIVES: To investigate the role of glycyrrhizin on TGFbeta1 stimulated signaling transduction in rat hepatic stellate cells (HSCs). METHODS: The mice HSCs were isolated and cultured with or without glycyrrhizin (1 micromol/L-1000 micromol/L) in vitro after TGFbeta1 stimulation. The mRNA level of Smad2, 3, 7 were measured with RT-PCR; protein expression level of Smad2, 3, 7 and collagen I, III were analyzed with Western blot. RESULTS: TGFbeta1 increased the mRNA level and protein expression of Smad2, 3, 7 in HSC; it also increased protein expression of collagen I and III. 1 micromol/L-1000 micromol/L glycyrrhizin decreased the mRNA level and protein expression of Smad2, 3, 7; it also inhibited protein expression of collagen I and III gradually. CONCLUSION: Interventing the TGFbeta signaling pathway and decreasing the synthesis of collagen, might be involved in the anti-fibrosis mechanism of glycyrrhizin.
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