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  • Title: Hydrolysis of plasmid DNA and RNA by amino alkyl naphthalimide as metal-free artificial nuclease.
    Author: Yang Q, Xu J, Sun Y, Li Z, Li Y, Qian X.
    Journal: Bioorg Med Chem Lett; 2006 Feb 15; 16(4):803-6. PubMed ID: 16314096.
    Abstract:
    A strategy of dimethylamino alkyldiimide conjugated with an intercalator of naphthalimide for hydrolysis of DNA was suggested and evaluated. 4 can hydrolyze 4 kb plasmid DNA into 2 kb fragments with GC and GG selectivity, which represents a novel example of sequence- or site-selective metal-free DNA artificial nuclease. Results also show it could hydrolyze RNA efficiently.
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