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  • Title: 2-Aminothiophene-3-carboxylates and carboxamides as adenosine A1 receptor allosteric enhancers.
    Author: Nikolakopoulos G, Figler H, Linden J, Scammells PJ.
    Journal: Bioorg Med Chem; 2006 Apr 01; 14(7):2358-65. PubMed ID: 16314104.
    Abstract:
    Three series of 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene and 2-amino-5,6,7,8-tetrahydrocyclohepta[b]thiophenes with 3-carboxylates and carboxamides have been prepared using the Gewald synthesis and evaluated as A(1)AR allosteric enhancers. The structure-activity relationships of these classes of compound are described. A number of compounds, notably 7b, are more potent and efficacious than PD81,723 (1).
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