These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Corticospinal disinhibition in paroxysmal kinesigenic dyskinesia.
    Author: Kang SY, Sohn YH, Kim HS, Lyoo CH, Lee MS.
    Journal: Clin Neurophysiol; 2006 Jan; 117(1):57-60. PubMed ID: 16314144.
    Abstract:
    OBJECTIVE: To investigate the underlying mechanism responsible for paroxysmal kinesigenic dyskinesia (PKD). METHODS: We performed a transcranial magnetic stimulation (TMS) study in 12 drug-naïve patients with PKD and 10 healthy volunteers. TMS parameters included resting motor threshold, recruitment curve of motor evoked potential amplitudes, short intracortical inhibition and facilitation, long intracortical inhibition (LICI), and silent period. We also measured compound muscle action potential. RESULTS: LICI, representing GABA-mediated inhibition, was significantly reduced in the patients (P = 0.033), while results for all other TMS parameters tested were comparable between the two groups. CONCLUSIONS AND SIGNIFICANCE: These results suggest that a specific type of corticospinal inhibitory mechanism is impaired in patients with PKD.
    [Abstract] [Full Text] [Related] [New Search]