These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Frequency of HPA-15a and HPA-15b (Gov a/b) human platelet alloantigens in the Croatian population.
    Author: Tomicic M, Bingulac-Popovic J, Drazic V, Hundric-Haspl Z.
    Journal: Arch Med Res; 2006 Jan; 37(1):172-4. PubMed ID: 16314205.
    Abstract:
    BACKGROUND: Human platelet antigen (HPA) genotyping is important for epidemiological studies because the prevalence of particular HPA allotypes differs among various populations and plays a major role in the occurrence of HPA alloimmunization. In Caucasians, antibodies to HPA-1a are the most important causes of neonatal alloimmune thrombocytopenia (NATP). Recent studies suggest that anti-HPA 15a/15b (Gov b, Gov a) might be the most likely candidate antibodies following anti-HPA-1a in inducing NATP. METHODS: In the present study, HPA-15 system genotype was determined by PCR-SSP method in 279 unrelated subjects from the Croatian population, yielding an HPA-15a and HPA-15b frequency of 0.53 and 0.47, respectively. RESULTS: Retrograde testing for the presence of anti-HPA-15 antibodies by use of MAIPA in 39 frozen serum samples from serologically negative cases of clinically suspect NATP produced negative results. CONCLUSION: The clinical role of anti-HPA-15 alloantibodies was unable to be confirmed.
    [Abstract] [Full Text] [Related] [New Search]