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  • Title: Studies on antidiarrhoeal activity of an extract of wine from Jacquez grapes in mice.
    Author: Vitali F, Bonina FP, Saija A, Tomaino A, Fonte G, Pennisi C, Tita B.
    Journal: Phytother Res; 2005 Nov; 19(11):924-7. PubMed ID: 16317645.
    Abstract:
    The present study was designed to verify the antidiarrhoeal effects of a lyophilized extract of wine from Jacquez grapes (Ord. Rhamnales; Fam. Vitaceae; Sp. Vitis aestivalis M.-cinerea E. x Vitis vinifera L.), studying its influence on castor oil-induced diarrhoea and enteropooling, and on gastrointestinal transit (measured by a charcoal marker) in mice. The pre-treatment of the animals with the JWE (Jacquez wine extract) produced a significant inhibition against castor oil induced-diarrhoea and intestinal fluid accumulation; furthermore the extract significantly decreased the propulsive movement of the charcoal meal. These findings suggest a potential beneficial use of the JWE in the treatment of diarrhoeal diseases.
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