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  • Title: Intrauterine therapy for parvovirus B19 infected symptomatic fetus using B19 IgG-rich high titer gammaglobulin.
    Author: Matsuda H, Sakaguchi K, Shibasaki T, Takahashi H, Kawakami Y, Furuya K.
    Journal: J Perinat Med; 2005; 33(6):561-3. PubMed ID: 16318623.
    Abstract:
    Parvovirus B19-infected hydrops fetalis was treated using gammaglobulin injection into the peritoneal cavity (GIFPeC) with B19-IgG-rich immunoglobulin. Fetal anemia and hydrops resolved, and B19-DNA in fetal ascites decreased despite no change in maternal B19-IgG or B19-DNA. Gammaglobulin injection into the peritoneal cavity is thus useful for treating hydrops fetalis while avoiding intrauterine blood-transfusion risks.
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