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  • Title: Alpha-adrenergic blockers on ventricular automatism in rat heart.
    Author: Tamargo J, Serrano J, García de Jalón P, de Andrés F.
    Journal: Rev Esp Fisiol; 1977 Mar; 33(1):63-6. PubMed ID: 16319.
    Abstract:
    The role of the alpha-adrenergic receptors in the genesis of cardiac arrhythmias induced in the isolated rat right ventricle has been studied. The administration of six alpha-adrenergic blocking agents (phenoxybenzamine, dibenamine, phentolamine, tolazoline, azapetine and SY-28) did not alter the automatism induced. Even when can not be excluded the existance of alpha-adrenergic receptors in the rat ventricle, it is clear that alpha-blocking drugs are ineffective to abolish the arrhythmias induced by an increase in the activity of the Purkinje fibers.
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