These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Cyclic diarylheptanoids inhibit cell-mediated low-density lipoprotein oxidation.
    Author: Kang HM, Ryong Kim J, Jeong TS, Choi SG, Ryu YH, Taeg Oh G, Baek NI, Kwon BM.
    Journal: Nat Prod Res; 2006 Feb; 20(2):139-43. PubMed ID: 16319007.
    Abstract:
    Two cyclic diarylheptanoids, garugamblin-3 (1) and acerogenin L (2), isolated from the MeOH extract of the fruits of Alnus japonica Steud., inhibited human low-density lipoprotein (LDL) oxidation in the thiobarbituric acid-reactive substance assay with IC50 values of 2.9 and 1.7 microM, respectively, and they also inhibited cell-mediated LDL oxidation more than five times more strongly than that of a well-known antioxidant, probucol, at a concentration of 10 microM. 1 had no effect on the anti-atherogenesis in low-density lipoprotein receptor- deficient mice.
    [Abstract] [Full Text] [Related] [New Search]