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  • Title: 5'-Porphyrin-oligonucleotide conjugates: neutral porphyrin-DNA interactions.
    Author: Balaz M, Steinkruger JD, Ellestad GA, Berova N.
    Journal: Org Lett; 2005 Dec 08; 7(25):5613-6. PubMed ID: 16321004.
    Abstract:
    [chemical reaction: see text]. Incorporation of hydrophilic tetraarylporphyrin phosphoramidites into the 5'-termimus of the DNA as well as noncharged porphyrin-DNA interactions have been studied. Porphyrin-modified oligonucleotides show lower melting temperatures than their unmodified analogues. Single-stranded DNA interacts more strongly with porphyrin and causes more intense chiral disturbance in the porphyrin environment than the corresponding double strand.
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