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  • Title: New Gly-Pro-Glu (GPE) analogues: expedite solid-phase synthesis and biological activity.
    Author: Alonso De Diego SA, Gutiérrez-Rodríguez M, Pérez de Vega MJ, Casabona D, Cativiela C, González-Muñiz R, Herranz R, Cenarruzabeitia E, Frechilla D, Del Río J, Jimeno ML, García-López MT.
    Journal: Bioorg Med Chem Lett; 2006 Mar 01; 16(5):1392-6. PubMed ID: 16321525.
    Abstract:
    A suitable solid-phase approach, based on Fmoc/(t)Bu methodology and on the use of 2-chlorotrityl resin, allowed a rapid and efficient preparation of new GPE analogues. Most of the synthesized tripeptides displayed glutamate receptor binding affinity comparable to that of GPE, but only a few derivatives showed significant neuroprotective activity.
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