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  • Title: Naphthofuroquinone derivatives: inhibition of receptor tyrosine kinases.
    Author: Lee KI, Park Y, Park SJ, Hwang JH, Lee SJ, Kim GD, Park WK, Lee S, Jeong D, Kong JY, Kang HK, Cho H.
    Journal: Bioorg Med Chem Lett; 2006 Feb; 16(3):737-42. PubMed ID: 16321529.
    Abstract:
    A series of dinaphtho[1,2-b;2',3'-d]furan-7,12-dione derivatives were synthesized and evaluated for inhibitory activities against receptor tyrosine kinases. The naphthofuroquinone compounds with dialkylaminoethoxy group at C(5)-position (7, 8, 10, and 11) manifested strong inhibitory activities against epidermal growth factor receptor and vascular endothelial growth factor receptor. Docking study of 11 with EGFR was also performed.
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