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  • Title: Serum S100beta protein in children with acute recurrent headache: a potentially useful marker for migraine.
    Author: Papandreou O, Soldatou A, Tsitsika A, Kariyannis C, Papandreou T, Zachariadi A, Papassotiriou I, Chrousos GP.
    Journal: Headache; 2005; 45(10):1313-6. PubMed ID: 16324163.
    Abstract:
    OBJECTIVE: To examine the role of glia-derived S100beta protein and to evaluate its use as a biochemical marker in childhood acute recurrent headache. METHODS: Twenty-five patients with acute recurrent headache (according to International Headache Society criteria) from our department's Headache Clinic were studied. Blood samples for measurement of serum S100beta were drawn: (1) < or = 3-hour post pain attack from our patients and (2) from 23 healthy controls. RESULTS: Of the 25 patients evaluated, 15 suffered from migraine and 10 from tension-type headache (TTH). Statistical analysis of the mean values of S100beta levels demonstrated a significant elevation in children with migraine headache, with values higher than those of both children with TTH and controls (P = .001). CONCLUSIONS: Our data suggest a direct relation between childhood migraine attacks and increased production of glial S100beta protein. Serum S100beta determination may be a useful biochemical marker for migraine in acute recurrent headache in childhood.
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