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  • Title: Type D personality is associated with increased levels of tumour necrosis factor (TNF)-alpha and TNF-alpha receptors in chronic heart failure.
    Author: Conraads VM, Denollet J, De Clerck LS, Stevens WJ, Bridts C, Vrints CJ.
    Journal: Int J Cardiol; 2006 Oct 26; 113(1):34-8. PubMed ID: 16325284.
    Abstract:
    BACKGROUND: Pro-inflammatory cytokines and their circulating receptors are powerful predictors of poor outcome in patients with chronic heart failure (CHF). We hypothesized that Type D personality, known to independently predict long-term mortality in patients with coronary heart disease, would relate to immune activation in CHF. METHODS: 91 stable CHF patients (79% males, mean age 57+/-13 yrs, 58% ischemic heart disease) with left ventricular ejection fraction <or=35% completed a psychological questionnaire to assess Type D personality (i.e., the tendency to experience negative emotions and to inhibit their expression). Plasma levels of tumour necrosis factor (TNF)-alpha, soluble TNF-alpha receptor 1 and 2 (sTNFR1 and sTNFR2) and interleukin-6 (IL-6) were measured by ELISA. RESULTS: Type D patients (n=30) had higher levels of TNF-alpha (5.1+/-2.9 versus 3.9+/-2.6 pg/ml, p=0.066), sTNFR1 (1656+/-1057 versus 1098+/-424 pg/ml, p=0.009) and sTNFR2 (2869+/-1510 versus 2011+/-794 pg/ml, p=0.006) as compared to non-Type D patients (n=61), whereas IL-6 was not different. After controlling for sex, age, ischemic etiology and disease severity, multivariate analysis yielded Type D as the strongest predictor of increased TNF-alpha (OR=2.9, p=0.048) and sTNFR2 levels (OR=3.9, p=0.018). For sTNFR1, the effect of Type D was no longer significant in this analysis (OR=2.7, p=0.112). CONCLUSIONS: Type D personality was independently associated with increased circulating levels of TNF-alpha and sTNFR2 in patients with CHF. This study provides the strongest evidence to date that chronic emotional distress may be associated with immune activation in heart failure.
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