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  • Title: Bladder perforation: a potential risk of early endovesical chemotherapy with mitomycin C.
    Author: Racioppi M, Porreca A, Foschi N, Delicato G, Destito A, D'Addessi A.
    Journal: Urol Int; 2005; 75(4):373-5. PubMed ID: 16327311.
    Abstract:
    The use of chemotherapeutic agents in the treatment of superficial bladder cancer is well known. In particular, mitomycin C (MMC) is globally accepted also in the early treatment after an endoscopic resection. Complications related to MMC are usually scarce as a systemic absorption is quite absent, while its use is effective for the bladder recurrence reduction. In our experience we report a female patient with a bladder perforation after an early instillation of a single dose of MMC. In this case, systemic toxicity occurred requiring subintensive care for a complete repair.
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