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  • Title: Structure-activity relationship studies on CXCR4 antagonists having cyclic pentapeptide scaffolds.
    Author: Tamamura H, Esaka A, Ogawa T, Araki T, Ueda S, Wang Z, Trent JO, Tsutsumi H, Masuno H, Nakashima H, Yamamoto N, Peiper SC, Otaka A, Fujii N.
    Journal: Org Biomol Chem; 2005 Dec 21; 3(24):4392-4. PubMed ID: 16327900.
    Abstract:
    Structure-activity relationship studies on CXCR4 antagonists, which were previously found by using cyclic pentapeptide libraries, were performed to optimize side-chain functional groups, involving conformationally constrained analogues. In addition, a new lead of cyclic pentapeptides with the introduction of a novel pharmacophore was developed.
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