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  • Title: Expression of pS2 gene in human breast cancer cell line MCF-7 is controlled by retinoic acid.
    Author: Hirota M, Furukawa Y, Hayashi K.
    Journal: Biochem Int; 1992 May; 26(6):1073-8. PubMed ID: 1632803.
    Abstract:
    We established a simplified method for the quantitative measurement of pS2 mRNA using the reverse transcriptase-polymerase chain reaction (RT-PCR) method. Expression of the pS2 gene, which is transcriptionally induced by estrogen in breast cancer cell line MCF-7 cells, can be repressed by retinoic acid (RA) in unstimulated cells. The suppressive effect of RA on pS2 mRNA was inhibited by cycloheximide.
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