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  • Title: Role of dietary l-arginine supplementation on serum parameters and intestinal enzyme activities in rats fed an excess-fat diet.
    Author: Taboada MC, Rodriguez B, Millán R, Míguez I.
    Journal: Biomed Pharmacother; 2006 Jan; 60(1):10-3. PubMed ID: 16330176.
    Abstract:
    We investigated whether dietary supplementation with L-arginine, the endogenous precursor of nitric oxide, might affect serum parameter levels body weight, food intake and activities of intestinal mucosa enzymes in animals fed with a standard diet or a diet high in saturated fat for 4 weeks. Body weight and food intake were not affected by diet but relative liver weight was higher in animals receiving a high-fat diet. Total cholesterol, LDL-cholesterol and triglyceride levels were higher in both groups fed high-fat diet and dietary L-arginine did not affect these parameters but produced an increase in serum protein levels and a slight decrease in glycaemia. Regarding the intestinal enzyme activities, rats fed a high-fat diet plus arginine showed the lowest intestinal disaccharidase activities.
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