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  • Title: Use of a new alginate film test to study the bactericidal efficacy of the high-level disinfectant ortho-phthalaldehyde.
    Author: Shackelford JC, Hanlon GW, Maillard JY.
    Journal: J Antimicrob Chemother; 2006 Feb; 57(2):335-8. PubMed ID: 16332730.
    Abstract:
    OBJECTIVES: To evaluate the merit of a new alginate efficacy film test to determine the bactericidal activity of the high-level disinfectant ortho-phthalaldehyde (OPA). METHODS: The efficacy of OPA was investigated using a new sodium alginate surface film test against Mycobacterium chelonae NCIMB 1474 and Epping, and Pseudomonas aeruginosa NCIMB 10421 under different test conditions. RESULTS: OPA was highly bactericidal against P. aeruginosa but its mycobactericidal efficacy was seriously reduced and produced >or=5 log reductions only at a concentration of 0.5% (w/v) within 30-60 min without organic load. CONCLUSIONS: The sodium alginate film efficacy was reproducible between repeats. Inactivation results depended upon the concentration of OPA, contact time, the presence of an organic load and the bacterial genera.
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