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  • Title: Multiple space-occupying lesions of the spleen in a case of Gaucher's disease.
    Author: Iwanami S, Namba K, Tsukada T, Hosaka T, Tagami M, Kubota A, Terada T.
    Journal: Intern Med; 1992 Apr; 31(4):557-60. PubMed ID: 1633369.
    Abstract:
    A 50-year-old female patient was admitted because of an enormously enlarged spleen and thrombocytopenia. Ultrasonography and magnetic resonance imaging revealed multiple space-occupying lesions in the spleen. She was diagnosed as having Gaucher's disease based on the low level of beta-glucosidase activity in leukocytes and Gaucher's cells present in bone marrow aspirate. Severe hypersplenism necessitated splenectomy. Pathological studies of the excised spleen, including ultrastructural examinations, demonstrated that multiple space-occupying lesions in the spleen were composed of typical Gaucher cells.
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