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  • Title: [Changes of morphology and erectile function of the cavernous tissues in spontaneously hypertensive rats].
    Author: Liu YF, Hu LQ, Zheng XM, Li SW, Yang ZW, Tian BQ.
    Journal: Zhonghua Nan Ke Xue; 2005 Nov; 11(11):832-4, 837. PubMed ID: 16333962.
    Abstract:
    OBJECTIVE: To study the changes of morphology and erectile function of the cavernous tissues in spontaneously hypertensive rats. METHODS: Spontaneously hypertensive male rats (SHR) (n = 15) and normotensive Wistar-Kyoto rats (WKY) (n = 15) were studied for 20 weeks. Systolic blood pressure (SBP) was measured weekly by the tail/cuff method. Erectile function was tested by injecting apomorphine (APO). The expression alpha-smooth muscle actin (alpha-SMA) and collagen III was examined by immunohistochemistry. RESULTS: SHR showed a higher systolic blood pressure (205.7 +/- 11.9 vs 114.3 +/- 10.2 mm Hg) and a lower erection frequency (0.6 +/- 0.5 vs 2.4 +/- 0.6). The expression of alpha-smooth muscle actin and collagen III in the cavernous tissues in the SHR was significantly higher than in the WKY. CONCLUSION: The erectile function of the penis is markedly affected by hypertension, and the pathological changes may be one of the most important mechanisms of decreased erectile function in SHR.
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