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  • Title: [Detection of glucocorticoid receptor-alpha mRNA expression using FQ-RT-PCR in nasal polyp].
    Author: Li P, Li Y, Zhang X, Zhang G, Ye J, Sun Y, Hu B.
    Journal: Lin Chuang Er Bi Yan Hou Ke Za Zhi; 2005 Sep; 19(17):769-71. PubMed ID: 16334247.
    Abstract:
    OBJECTIVE: To detect the expression of the glucocorticoid receptor-alpha (GR-alpha) mRNA in nasal polyp and normal nasal mucosa and investigate the significance of GR-alpha in progression of nasal polyp. METHOD: The expression of GR-alpha mRNA in 36 samples of nasal polyp and 31 samples of normal nasal mucosa was examined by using fluorescent quantitative PCR(FQ RT-PCR). RESULT: The GR-alpha mRNA levels in normal nasal mucosa [(135.4 +/- 5.2) x 10(10) copy/g] were significantly higher than those in nasal polyp [(25.5 +/- 5.0) x 10(10) copy/g] (P < 0.01). CONCLUSION: The low expression of GR-alpha mRNA in nasal polyp is related to the progression of nasal polyp.
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