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  • Title: [Expression of A-type atrial natriuretic peptide receptor in the kidneys of renovascular hypertension rats and its implication].
    Author: Liu RT, Xiao J, Guo HL, Qiu DG, Yin HH, Wang ZR.
    Journal: Sichuan Da Xue Xue Bao Yi Xue Ban; 2005 Nov; 36(6):776-8. PubMed ID: 16334550.
    Abstract:
    OBJECTIVE: To investigate the expression of A-type atrial natriuretic peptide receptor (ANPR-A) in the kidneys of renovascular hypertension rats and evaluate the significance of the expression. METHODS: The rat model of renovascular hypertension was produced by constricting one lateral renal artery. After the renal artery being constricted for 4 weeks and 8 weeks, the systolic BP of rats was measured with a manometer using the tail-cuff method. Then, the expression of ANPR-A was respectively detected by immunohistochemical technique in the kidneys of the two-kidney, one-clip (2K1C) rats, and the expression level of ANPR-A was semi-quantitatively measured by Mias-2000 computer image analyzer. RESULTS: At 4 weeks after the artery-constricted operation,the expression of ANPR-A increased significantly in 2K1C hypertensive rat glomeruli and decreased significantly in renal tubules, compared with control (P<0.01), but there was no marked change in medullar collecting tubules. At 8 weeks after the artery-constricted operation, the expression of ANPR-A decreased significantly in 2K1C hypertensive rat renal tubules and medullar collecting tubules, compared with control (P<0.01); however, there was weak expression in glomeruli, and no statistically significant difference was seen when compared with control (P>0.05). CONCLUSION: The expression of ANPR-A decreased significantly in kidney tissues of renovascular
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