These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Telomerase activity in esophageal squamous cell carcinoma and lesions unstained with Lugol's solution.
    Author: Yoneyama K, Yasumoto S, Aoyama N, Koizumi H, Imada T, Takanashi Y.
    Journal: Hepatogastroenterology; 2005; 52(66):1734-7. PubMed ID: 16334768.
    Abstract:
    BACKGROUND/AIMS: Telomerase is a ribonucleoprotein enzyme that protects erosion of telomeres at the ends of chromosomes and its activity has been detected in immortalized cells and most human cancers. METHODOLOGY: We analyzed telomerase activity in primary esophageal squamous cell carcinomas (SCCs) without any preoperative treatment and lesions unstained with Lugol's solution, using a telomeric repeat amplification protocol (a TRAP) assay. RESULTS: Strong telomerase activities were detected in all resected specimens of esophageal SCCs, and in 33 of 40 endoscopic biopsy specimens of lesions unstained with Lugol's solution. Among lesions unstained with Lugol's solution, 19 of 19 esophageal SCCs, and 13 of 13 dysplasias, which are considered as clinically precancerous lesions had strong telomerase activities. CONCLUSIONS: These results indicate that reactivation of telomerase may occur at an early stage in the carcinogenesis of esophageal SCCs, and telomerase activity may be a practically useful molecular biological marker for supporting the diagnosis of early esophageal SCCs.
    [Abstract] [Full Text] [Related] [New Search]