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  • Title: [A study on the promoting effects of recombinant human epidermal growth factor on skin wound healing in rats].
    Author: Zheng J, Huang XY, Wei X.
    Journal: Zhonghua Zheng Xing Wai Ke Za Zhi; 2005 Sep; 21(5):379-83. PubMed ID: 16335388.
    Abstract:
    OBJECTIVE: To observe the effects of recombinant human epidermal growth factor (rhEGF) on skin wound healing. METHODS: The dorsal trauma model of rats was used. A total of 68 dorsal wounds in 34 rats were created and divided into the rhEGF group and the isotonic saline group according to self-control. The process of wound healing was observed and a mean healing time was calculated. Furthermore, the dynamic analysis was performed at different times on wound OHP contents, ratio of collagen I/III and cell DNA cycle. RESULTS: The wound healing was accelerated obviously in all wounds treated with rhEGF. The mean time of wound healing of the two groups was (17.2 +/- 1.3) days and (20.5 +/- 1.6) days respectively (P < 0.01). In the rhEGF group, the new granulation tissue was more and the re-epithelialization was faster than that of the saline group. External rhEGF increased OHP content, reduced collagen I/II ratio and accelerated cell DNA replication. CONCLUSION: External rhEGF can shorten wound healing time, increase granulation tissue and OHP contents, reduce collagen I/III ratio and accelerate cell DNA replication, thus obviously promoting skin wound repair.
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