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  • Title: Cofilin phosphatases and regulation of actin dynamics.
    Author: Huang TY, DerMardirossian C, Bokoch GM.
    Journal: Curr Opin Cell Biol; 2006 Feb; 18(1):26-31. PubMed ID: 16337782.
    Abstract:
    Cofilin is a ubiquitous actin-binding factor required for the reorganization of actin filaments in eukaryotes. The dephosphorylation of cofilin enables its actin severing and depolymerizing activity and drives directional cell motility, thus providing a simple phosphoregulatory mechanism for actin reorganization. To date, two cofilin-specific phosphatases have been identified: Slingshot and Chronophin. These cofilin phosphatases are unrelated in sequence and regulatory properties, each potentially providing a unique mechanism for cofilin activation under varying biological circumstances.
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