These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Evaluation of the protective effect of magnesium on amikacin ototoxicity by electrophysiologic tests in guinea pigs].
    Author: Bulut E, Yağiz R, Taş A, Uzun C, Yildirim C, Kaymak K, Karasalioğlu AR.
    Journal: Kulak Burun Bogaz Ihtis Derg; 2005; 15(3-4):70-7. PubMed ID: 16340296.
    Abstract:
    OBJECTIVES: This experimental study was performed to evaluate the protective effect of magnesium on amikacin ototoxicity. STUDY DESIGN: Twenty-seven guinea pigs (54 ears) with normal auropalpebral reflexes and otomicroscopic examination, auditory brain stem responses (ABR), and transient evoked otoacoustic emissions (TEOAE) were randomly divided into four groups to receive amikacin once 15 mg/kg daily (group 1 and 3) and twice 7.5 mg/kg daily (group 2 and 4) for seven days. Groups 3 and 4 were administered oral MgCl an hour after amikacin use at a dose of 39 mmol/l and 19.5 mmol/l, respectively, for seven days. Otomicroscopic examination, ABR and TEOAE measurements were repeated on the third, fifth, and seventh days. RESULTS: Compared to group 1, decreases in TEOAE amplitudes and reproducibility and increases in ABR thresholds were significant in group 2 (p<0.05). However, in groups 3 and 4, TEOAE amplitudes remained unchanged, or even increased and the reproducibility of TEOAE responses and ABR thresholds showed no significant changes (p>0.05). CONCLUSION: Our data show that oral magnesium may play a protective role on amikacin ototoxicity.
    [Abstract] [Full Text] [Related] [New Search]