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  • Title: [Design and synthesis of quinoxaline derivatives and their antitumor activities].
    Author: Zhao CH, Chen Y, Ding J, Duan WH.
    Journal: Yao Xue Xue Bao; 2005 Sep; 40(9):814-9. PubMed ID: 16342683.
    Abstract:
    AIM: To design and synthesize novel quinoxaline derivatives as antitumor agents. METHODS: Using 4-chloro-2-nitroaniline as a starting compound, followed by substitution, reductive cyclization, oxidation, and chlorination, to give the key intermediate 2,7-dichloroquinoxaline (7), which reacted with different phenolic compounds to afford quinoxaline derivatives. RESULTS: The structures of the target molecules were characterized by elemental analysis, 1H NMR, MS, and IR. CONCLUSION: At concentration of 1 x 10(-4) mol x L(-1), some of the derivatives showed equal antitumor activities to XK469.
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