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  • Title: Pentraxins as a key component of innate immunity.
    Author: Bottazzi B, Garlanda C, Salvatori G, Jeannin P, Manfredi A, Mantovani A.
    Journal: Curr Opin Immunol; 2006 Feb; 18(1):10-5. PubMed ID: 16343883.
    Abstract:
    Pentraxins are a complex superfamily of multifunctional molecules characterized by a multimeric structure. C-reactive protein and pentraxin 3 (PTX3) are prototypic molecules of the short and long pentraxin family, respectively. PTX3 is conserved in evolution and produced by innate immune cells. Evidence suggests that PTX3 acts as a non-redundant component of the humoral arm of innate immunity, downstream of, and complementary to, cellular recognition, as well as a tuner of inflammation.
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