These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Synthesis, characterization, and antitumor activity of new chloroethylamine platinum complexes.
    Author: Khokhar AR, Xu Q, Newman RA, Kido Y, Siddik ZH.
    Journal: J Inorg Biochem; 1992 Feb 15; 45(3):211-9. PubMed ID: 1634893.
    Abstract:
    A series of cis-bis-(2-chloroethylamine)platinum(II) and platinum(IV) complexes were synthesized and characterized by elemental analysis, IR, and 1H and 195Pt NMR spectroscopic techniques. Complexes were tested in vitro against murine L1210 leukemia and human ovarian A2780 cell lines and in vivo against the L1210 leukemia model. Some of these complexes showed excellent antitumor activity in both systems. However, all were inactive against cisplatin-resistant A2780/CP cells.
    [Abstract] [Full Text] [Related] [New Search]