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  • Title: Pure red cell aplasia in a prostate cancer patient treated with leuprolide acetate and chlormadinone acetate.
    Author: Kobayashi M, Nukui A, Morita T.
    Journal: Int J Urol; 2005 Nov; 12(11):1010-1. PubMed ID: 16351663.
    Abstract:
    Pure red cell aplasia (PRCA) is characterized by anemia with reticulocytopenia but with normal leukocyte and platelet counts, and a bone marrow with a selective absence of erythroid precursor cells. Drug-induced PRCA is a rare secondary form of PRCA, and is usually acute and fully reversible by the withdrawal of the causative drugs. We report a rare case of PRCA in a prostate cancer patient treated with combined androgen blockade (CAB) consisted of leuprolide acetate as a luteinizing hormone-releasing hormone agonist and chlormadinone acetate as an antiandrogen. This case demonstrated that these drugs could be a cause of PRCA, and suggests that regular close monitoring for anemia is needed in prostate cancer patients treated with these drugs.
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